Family, Friends Seem Best at Spotting Early
THURSDAY, Sept. 30 (HealthDay News) -- When it comes to the
onset of early Alzheimer's disease, a person's family and close
friends are better able to spot the initial signs of trouble than
traditional screening by doctors, new research suggests.
The finding, reported online in the journal
Brain, is based on the apparent accuracy of observations gathered from family and friends in response to a carefully designed dementia questionnaire that is available in several languages and is already in use in clinics worldwide.
Called Ascertain Dementia 8 (or AD8), the questionnaire is
designed to draw out observations on someone's judgment, activity
levels, learning capacity, forgetfulness, repetitiveness and
overall thinking skills.
Answers given by family and friends to the questionnaire, which
can be completed in two minutes, appear to correlate accurately
with biological indicators of Alzheimer's disease more often than
standard physician testing, the researchers found.
They evaluated data from questionnaires about more than 250
people who had completed traditional screenings for dementia and
had been given spinal fluid tests and brain plaque scans to look
for biological markers of the disease.
"Based on our results, the AD8 appears to be superior to conventional testing in its ability to detect signs of early dementia," co-author Dr. John C. Morris, director of the Knight Alzheimer's Disease Research Center at the Washington University School of Medicine in St. Louis, said in a university news release.
"It can't tell us whether the dementia is caused by Alzheimer's or other disorders, but it lets us know when there's a need for more extensive evaluations to answer that question," he explained.
Morris also suggested that the questionnaire technique could
serve as a fast and inexpensive answer to the financial hurdle of
testing all potential Alzheimer's disease patients for disease
"The AD8 gives us a brief and very low-cost alternative that takes a few minutes . . . to screen for dementia and thus identify those individuals who need follow-up evaluations to determine if there truly are signs of Alzheimer's," he said.
Family- and friend-driven observations, based on continuous
close contact, also may give a better picture of the progression of
disease, he said, given that a test at a doctor's office can give
only a snapshot of the person's condition at a single moment in
"These informants can give us the retrospective perspective we need to know that a person's mental abilities have begun to meaningfully decline, indicating that additional testing is needed," Morris said.
The U.S. National Institute on Aging has more on
diagnosing Alzheimer's disease.
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